ALB Schedule -- 2021 Ann Arbor AirMax
Regular season
| Primary |
| Date | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 3/29/2021 | | BCK | W | 4-0 | | Carrasco | R | Carrasco | | Kim | L |
| 3/30/2021 | | BCK | L | 1-5 | | Skubal | L | Skubal | | Fleming | L |
| 4/1/2021 | @ | LAW | L | 1-3 | | Civale | R | Civale | | Maeda | R |
| 4/2/2021 | @ | LAW | W | 6-4 | 12 | Weaver | R | Hand | Pagan | Wainwright | R |
| 4/4/2021 | | POW | L | 3-4 | | Boyd | L | Pagan | | Anderson,Ty | L |
| 4/5/2021 | | POW | L | 3-7 | | Carrasco | R | Carrasco | | Ryu | L |
| 4/6/2021 | @ | NIN | L | 2-5 | | Skubal | L | Skubal | | Kelly,M | R |
| 4/8/2021 | | EXP | L | 3-14 | | Civale | R | Civale | | Antone | R |
| 4/9/2021 | @ | DRT | L | 1-3 | | Weaver | R | Weaver | | Darvish | R |
| 4/10/2021 | @ | DRT | L | 3-5 | | Boyd | L | Boyd | | Walker,T | R |
| 4/11/2021 | @ | STA | W | 6-2 | | Carrasco | R | Carrasco | Hand | Gonsolin | R |
| 4/12/2021 | @ | STA | W | 7-5 | | Skubal | L | Reyes,A | Hand | Brault | L |
| 4/13/2021 | @ | STA | L | 3-4 | | Civale | R | Civale | | Gomber | L |
| 4/14/2021 | @ | NIN | W | 7-5 | | Weaver | R | Weems | Barnes,M | Manaea | L |
| 4/15/2021 | @ | NIN | L | 0-9 | | Boyd | L | Boyd | | Cole,G | R |
| 4/16/2021 | @ | NIN | W | 6-3 | | Carrasco | R | Carrasco | Hand | Anderson,I | R |
| 4/17/2021 | | EXP | L | 2-4 | | Skubal | L | Skubal | | Woodruff | R |
| 4/18/2021 | | EXP | W | 11-10 | 12 | Civale | R | Wittgren | | Keuchel | L |
| 4/19/2021 | @ | 8TH | L | 4-5 | | Weaver | R | Weems | | Fried | L |
| 4/20/2021 | | BOM | L | 4-5 | | Boyd | L | Crichton | | Bubic | L |
| 4/21/2021 | | BOM | W | 13-1 | | Carrasco | R | Carrasco | | Kuhl | R |
| 4/23/2021 | | OUT | L | 1-2 | | Skubal | L | Skubal | | Alzolay | R |
| 4/24/2021 | | OUT | W | 7-5 | | Civale | R | Civale | Hand | Snell | L |
| 4/27/2021 | | SLG | L | 3-8 | | Weaver | R | Weaver | | McCullers | R |
| 4/28/2021 | | SLG | W | 5-4 | 10 | Boyd | L | Hand | | Morton | R |
| 4/29/2021 | @ | EXP | L | 2-13 | | Carrasco | R | Carrasco | | Suter | L |
| 4/30/2021 | @ | EXP | L | 2-5 | | Skubal | L | Skubal | | Woodruff | R |
| 5/1/2021 | @ | EXP | L | 2-7 | | Civale | R | Civale | | Keuchel | L |
| 5/2/2021 | | 8TH | L | 2-8 | | Weaver | R | Weaver | | Bassitt | R |
| 5/3/2021 | @ | NIN | L | 2-5 | | Boyd | L | Boyd | | Kelly,M | R |
| 5/5/2021 | @ | BLA | L | 3-5 | | Carrasco | R | Carrasco | | Heaney | L |
| 5/6/2021 | @ | BLA | L | 4-6 | | Skubal | L | Reyes,A | | Happ,JA | L |
| 5/8/2021 | | 8TH | W | 7-6 | | Civale | R | Hand | | Bassitt | R |
| 5/9/2021 | | WW | W | 9-8 | 11 | Weaver | R | Reyes,A | | Berrios | R |
| 5/10/2021 | | WW | L | 1-15 | | Boyd | L | Boyd | | Sheffield | L |
| 5/11/2021 | @ | NIN | L | 1-5 | | Weems | R | Barnes,M | | Cole,G | R |
| 5/12/2021 | @ | NIN | L | 1-9 | | Skubal | L | Skubal | | Anderson,I | R |
| 5/13/2021 | @ | 8TH | W | 4-2 | 11 | Civale | R | Crichton | | Bassitt | R |
| 5/14/2021 | @ | 8TH | L | 2-7 | | Weaver | R | Weaver | | Duffy | L |
| 5/15/2021 | @ | 8TH | W | 7-5 | 11 | Boyd | L | Wittgren | Crichton | Fried | L |
| 5/16/2021 | @ | STA | L | 2-3 | | Brubaker | R | Brubaker | | Quantrill | R |
| 5/17/2021 | @ | STA | L | 5-15 | | Skubal | L | Skubal | | Gonsolin | R |
| 5/18/2021 | | DRT | L | 3-5 | | Civale | R | Civale | | Richards,G | R |
| 5/19/2021 | | DRT | L | 3-6 | | Weaver | R | Weaver | | Perez,Ma | L |
| 5/20/2021 | | DRT | L | 1-6 | | Boyd | L | Boyd | | Cahill | R |
| 5/21/2021 | | MB | L | 4-7 | | Brubaker | R | Brubaker | | Keller,M | R |
| 5/22/2021 | | MB | L | 1-4 | | Skubal | L | Reyes,A | | Bieber | R |
| 5/23/2021 | @ | BOM | L | 9-10 | | Civale | R | Trivino | | Kuhl | R |
| 5/24/2021 | @ | BOM | W | 6-2 | | Weaver | R | Reyes,A | Weems | Dunn | R |
| 5/26/2021 | @ | TUA | L | 3-17 | | Boyd | L | Boyd | | Kikuchi | L |
| 5/27/2021 | @ | TUA | L | 5-7 | | Weems | R | Barnes,M | | Buehler | R |
| 5/28/2021 | @ | FUR | L | 2-7 | | Skubal | L | Skubal | | Gray,S | R |
| 5/29/2021 | @ | FUR | L | 6-7 | | Civale | R | Hand | | Fairbanks | R |
| 5/30/2021 | @ | 8TH | L | 5-14 | | Weaver | R | Weaver | | Musgrove | R |
| 5/31/2021 | | 8TH | L | 0-1 | | Boyd | L | Boyd | | Fried | L |
| 6/1/2021 | @ | ROO | L | 0-3 | | Hernandez,Ca | R | Hernandez,Ca | | Wheeler | R |
| 6/2/2021 | @ | ROO | L | 5-9 | | Skubal | L | Skubal | | Houser | R |
| 6/3/2021 | @ | ROO | L | 2-4 | | Civale | R | Civale | | Kremer | R |
| 6/4/2021 | | DRT | L | 3-6 | | Weaver | R | Weaver | | Richards,G | R |
| 6/5/2021 | | DRT | L | 2-6 | | Boyd | L | Boyd | | Perez,Ma | L |
| 6/7/2021 | @ | WW | W | 5-3 | | Hernandez,Ca | R | Trivino | Hand | Ynoa | R |
| 6/8/2021 | @ | WW | L | 3-5 | | Skubal | L | Skubal | | Burnes | R |
| 6/9/2021 | @ | SLG | L | 7-9 | 12 | Civale | R | Hand | | Nola,Aa | R |
| 6/10/2021 | @ | SLG | W | 8-1 | | Weaver | R | Weaver | Pagan | Castillo,L | R |
| 6/11/2021 | | NIN | L | 4-6 | | Boyd | L | Boyd | | Canning | R |
| 6/12/2021 | | 8TH | L | 5-7 | | Hernandez,Ca | R | Hernandez,Ca | | Bassitt | R |
| 6/13/2021 | | SLG | L | 4-8 | | Skubal | L | Skubal | | Morton | R |
| 6/14/2021 | | SLG | L | 0-1 | | Civale | R | Civale | | Nola,Aa | R |
| 6/15/2021 | @ | OUT | W | 5-1 | | Weaver | R | Weaver | | Plesac | R |
| 6/16/2021 | @ | OUT | W | 4-1 | | Boyd | L | Boyd | Reyes,A | Lynn | R |
| 6/17/2021 | | BLA | L | 4-5 | 10 | Brubaker | R | Hand | | Cody | R |
| 6/18/2021 | | BLA | L | 1-2 | | Skubal | L | Pagan | | Heaney | L |
| 6/19/2021 | | HEN | L | 3-6 | | Civale | R | Civale | | May,D | R |
| 6/20/2021 | | HEN | W | 10-6 | | Weaver | R | Weaver | | Hudson,Dak | R |
| 6/21/2021 | | 8TH | W | 5-4 | 10 | Boyd | L | Hand | | Senzatela | R |
| 6/22/2021 | | 8TH | W | 7-6 | | Brubaker | R | Trivino | Hand | Bassitt | R |
| 6/23/2021 | | 8TH | W | 11-4 | | Skubal | L | Skubal | Hand | Duffy | L |
| 6/24/2021 | @ | POW | L | 0-3 | | Civale | R | Trivino | | Ryu | L |
| 6/25/2021 | @ | POW | L | 2-3 | | Weaver | R | Weaver | | Fedde | R |
| 6/26/2021 | @ | LAW | W | 5-2 | | Boyd | L | Boyd | Reyes,A | Wainwright | R |
| 6/27/2021 | @ | LAW | L | 1-6 | | Brubaker | R | Brubaker | | Clevinger | R |
| 6/28/2021 | | BUL | W | 6-4 | | Skubal | L | Weems | Wittgren | Kershaw | L |
| 6/29/2021 | | BUL | W | 5-3 | | Civale | R | Civale | Weems | Marquez,G | R |
| 6/30/2021 | @ | MB | W | 6-5 | 12 | Weaver | R | Crichton | Hernandez,Ca | Lopez,P | R |
| 7/1/2021 | @ | MB | L | 4-7 | | Boyd | L | Boyd | | Singer | R |
| 7/2/2021 | @ | MB | L | 6-10 | | Brubaker | R | Crichton | | Mills | R |
| 7/3/2021 | @ | BCK | L | 1-5 | | Skubal | L | Skubal | | Kim | L |
| 7/4/2021 | @ | BCK | L | 3-14 | | Civale | R | Civale | | Fleming | L |
| 7/5/2021 | @ | 8TH | L | 1-7 | | Weaver | R | Weaver | | Fried | L |
| 7/6/2021 | @ | 8TH | L | 0-2 | | Boyd | L | Boyd | | Senzatela | R |
| 7/7/2021 | | TUA | L | 3-7 | | Brubaker | R | Brubaker | | Valdez,F | L |
| 7/8/2021 | | TUA | W | 13-1 | | Skubal | L | Skubal | | Buehler | R |
| 7/10/2021 | | MB | W | 6-4 | | Civale | R | Civale | Pagan | Keller,M | R |
| 7/11/2021 | | MB | L | 0-4 | | Weaver | R | Weaver | | Bieber | R |
| 7/13/2021 | | STA | L | 4-6 | | Boyd | L | Boyd | | Houck | R |
| 7/14/2021 | | STA | W | 4-2 | | Hernandez,Ca | R | Weems | Barnes,M | Gonsolin | R |
| 7/15/2021 | | STA | L | 4-6 | 12 | Skubal | L | Barnes,M | | Brault | L |
| 7/16/2021 | | STA | L | 2-10 | | Civale | R | Civale | | Keller,B | R |
| 7/18/2021 | | BCK | W | 6-2 | | Weaver | R | Crichton | | Anderson,Bre | L |
| 7/19/2021 | | BCK | W | 6-2 | | Boyd | L | Reyes,A | | Shoemaker | R |
| 7/20/2021 | | LAW | L | 0-7 | | Brubaker | R | Brubaker | | deGrom | R |
| 7/21/2021 | | LAW | L | 4-7 | | Skubal | L | Skubal | | May,D | R |
| 7/22/2021 | | LAW | L | 4-9 | | Civale | R | Civale | | Maeda | R |
| 7/23/2021 | | KNT | W | 5-2 | | Weaver | R | Weaver | Crichton | Gausman | R |
| 7/24/2021 | | KNT | L | 3-8 | | Boyd | L | Boyd | | Barria | R |
| 7/25/2021 | | KNT | L | 5-6 | | Brubaker | R | Brubaker | | Urias,J | L |
| 7/26/2021 | @ | KNT | W | 4-2 | | Skubal | L | Pagan | Wittgren | Sanchez,S | R |
| 7/27/2021 | @ | KNT | L | 4-9 | | Civale | R | Civale | | Smyly | L |
| 7/28/2021 | @ | KNT | L | 3-7 | | Weaver | R | Weaver | | Gausman | R |
| 7/29/2021 | @ | HAM | L | 1-11 | | Boyd | L | Boyd | | Glasnow | R |
| 7/30/2021 | @ | HAM | L | 0-10 | | Brubaker | R | Brubaker | | Carrasco | R |
| 7/31/2021 | | ROO | W | 7-2 | | Skubal | L | Weems | | Wheeler | R |
| 8/1/2021 | | ROO | L | 2-4 | | Civale | R | Civale | | Menez | L |
| 8/2/2021 | | ROO | W | 5-4 | | Weaver | R | Crichton | | Kremer | R |
| 8/3/2021 | | HAM | L | 1-6 | | Boyd | L | Boyd | | Glasnow | R |
| 8/4/2021 | | HAM | L | 3-7 | | Brubaker | R | Brubaker | | Carrasco | R |
| 8/6/2021 | @ | EXP | L | 4-9 | | Skubal | L | Skubal | | Suter | L |
| 8/7/2021 | @ | EXP | W | 2-1 | | Civale | R | Pagan | Weems | Woodruff | R |
| 8/8/2021 | @ | MB | L | 5-8 | | Weaver | R | Weaver | | Lopez,P | R |
| 8/9/2021 | @ | MB | L | 2-15 | | Boyd | L | Boyd | | Singer | R |
| 8/10/2021 | | NIN | W | 8-6 | | Weems | R | Barnes,M | Maton | Kelly,M | R |
| 8/11/2021 | | NIN | L | 5-10 | 12 | Skubal | L | Reyes,A | | Canning | R |
| 8/12/2021 | | NIN | L | 1-13 | | Civale | R | Civale | | Manaea | L |
| 8/13/2021 | @ | JAB | L | 1-9 | | Weaver | R | Weaver | | Wood | L |
| 8/14/2021 | @ | JAB | L | 2-6 | | Boyd | L | Boyd | | Bauer | R |
| 8/15/2021 | | PIN | L | 6-7 | 10 | Brubaker | R | Weems | | Tanaka | R |
| 8/16/2021 | | PIN | L | 0-5 | | Skubal | L | Skubal | | Fiers | R |
| 8/18/2021 | @ | KNT | L | 6-13 | | Civale | R | Crichton | | Sanchez,S | R |
| 8/19/2021 | @ | SLG | L | 5-10 | | Weaver | R | Weaver | | Garcia,D | R |
| 8/20/2021 | @ | SLG | L | 1-3 | | Boyd | L | Reyes,A | | McCullers | R |
| 8/21/2021 | @ | SLG | L | 2-6 | | Brubaker | R | Brubaker | | Morton | R |
| 8/22/2021 | | ROO | L | 1-3 | | Skubal | L | Quantrill | | Houser | R |
| 8/23/2021 | | ROO | L | 1-8 | | Civale | R | Civale | | Kremer | R |
| 8/25/2021 | @ | PIN | L | 2-8 | | Weaver | R | Weaver | | Lamet | R |
| 8/26/2021 | @ | PIN | L | 3-9 | | Boyd | L | Boyd | | Oviedo | R |
| 8/27/2021 | | LAW | L | 1-2 | | Brubaker | R | Brubaker | | Wainwright | R |
| 8/28/2021 | | LAW | L | 2-5 | | Skubal | L | Weems | | deGrom | R |
| 8/29/2021 | | EXP | W | 8-6 | | Civale | R | Clarke | | Woodruff | R |
| 8/31/2021 | | NIN | W | 6-3 | | Weaver | R | Weaver | | Canning | R |
| 9/1/2021 | | NIN | L | 0-7 | | Boyd | L | Boyd | | Manaea | L |
| 9/2/2021 | | NIN | W | 3-0 | | Clarke | R | Clarke | Pagan | Cole,G | R |
| 9/4/2021 | | JAB | L | 4-6 | | Skubal | L | Reyes,A | | Minor | L |
| 9/5/2021 | | JAB | L | 1-7 | | Civale | R | Civale | | Bauer | R |
| 9/7/2021 | @ | ROO | W | 7-2 | | Weaver | R | Weaver | | Velasquez | R |
| 9/9/2021 | @ | BUL | L | 1-3 | | Boyd | L | Boyd | | Giolito | R |
| 9/10/2021 | @ | BUL | L | 5-12 | | Brubaker | R | Brubaker | | Kershaw | L |
| 9/12/2021 | | FUR | L | 1-3 | | Skubal | L | Pagan | | Hendricks | R |
| 9/13/2021 | | FUR | L | 0-9 | | Civale | R | Civale | | Gray,S | R |
| 9/14/2021 | @ | BCK | L | 3-4 | | Weaver | R | Crichton | | Anderson,Bre | L |
| 9/15/2021 | @ | BCK | W | 6-2 | | Boyd | L | Boyd | Reyes,A | Shoemaker | R |
| 9/16/2021 | @ | BCK | L | 0-9 | | Brubaker | R | Brubaker | | Kim | L |
| 9/18/2021 | @ | DRT | L | 2-3 | | Skubal | L | Skubal | | Richards,G | R |
| 9/19/2021 | @ | DRT | L | 1-4 | | Civale | R | Civale | | Perez,Ma | L |
| 9/20/2021 | | EXP | L | 2-7 | | Weaver | R | Weaver | | Freeland | L |
| 9/21/2021 | | EXP | W | 3-2 | | Boyd | L | Reyes,A | | Suter | L |
| 9/22/2021 | | EXP | W | 6-2 | | Brubaker | R | Brubaker | Wittgren | Woodruff | R |
| 9/23/2021 | @ | EXP | L | 0-5 | | Skubal | L | Skubal | | Keuchel | L |
| 9/24/2021 | @ | EXP | L | 1-14 | | Civale | R | Civale | | McKenzie | R |
| 9/25/2021 | | KNT | L | 5-8 | | Weaver | R | Weaver | | Gausman | R |
| 9/26/2021 | | KNT | L | 0-3 | | Boyd | L | Boyd | | Barria | R |
| 9/27/2021 | @ | HEN | L | 6-7 | | Brubaker | R | Barnes,M | | Gallen | R |
| 9/28/2021 | @ | HEN | L | 1-9 | | Skubal | L | Skubal | | Corbin | L |